![]() To explore possible causal association of AChE-R changes with thymic composition and function, we used an AChE-R transgenic model and showed smaller thymic medulla compared with strain-matched controls, indicating that AChE-R overexpression interferes with thymic differentiation mechanisms. We found lower hydrolytic activities in the MG thymus compared with adult controls, accompanied by translocation of AChE-R from the cytoplasm to the membrane and increased expression of the signaling protein kinase PKC-βII. The objectives of this study were to analyze the involvement of AChE variants in thymic hyperplasia. MG is associated with thymic hyperplasia, showing signs of inflammation. Autoimmune myasthenia gravis (MG) is mediated by antibodies to the acetylcholine receptor and current therapy is based on anti-AChE drugs. ![]() ![]() Cholinergic signaling and acetylcholinesterase (AChE) influence immune response and inflammation.
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